Farxiga (dapagliflozin) dosing, indications, interactions, adverse effects, and more (2023)

Patient Education
dapagliflozin oral

DAPAGLIFLOZIN - ORAL

(DAP-a-gli-FLOE-zin)

(Video) Dapagliflozin - Mechanism, side effects, precautions & uses

COMMON BRAND NAME(S): Farxiga

USES: Dapagliflozin is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. This medication is also used in people with type 2 diabetes and heart disease to lower the risk of going to the hospital for heart failure. Dapagliflozin works by increasing the removal of sugar by your kidneys.Dapagliflozin is also used to treat kidney disease and heart failure. It may help you live longer and lower your risk of going to the hospital for heart failure. Dapagliflozin works by increasing the removal of sodium by your kidneys.

HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking dapagliflozin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. The dosage is based on your medical condition and response to treatment.Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.Tell your doctor if your condition does not improve or if it worsens.

(Video) 7 Farxiga Side Effects You Should Not Ignore | Farxiga (Dapagliflozin) For Diabetes

SIDE EFFECTS: Frequent urination, dizziness, or lightheadedness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: signs of a urinary tract infection (such as burning/painful/frequent/urgent urination, pink/bloody urine), signs of kidney problems (such as change in the amount of urine, swelling legs/feet).Get medical help right away if you have any very serious side effects, including: unusual tiredness, nausea/vomiting, stomach/abdominal pain, trouble breathing.Dapagliflozin can sometimes cause painful urination or pink/bloody urine that are usually signs of a urinary tract infection, but they may also be signs of a rare condition (bladder cancer). Bladder cancer may or may not be caused by dapagliflozin. Tell your doctor right away if you develop these symptoms.This medication may cause a new yeast infection in the vagina or the penis. It may also cause a rare but very serious bacterial infection in the genital/anal area (Fournier's gangrene) in people with type 2 diabetes. Tell your doctor right away if you have signs of a yeast infection in the vagina (such as unusual vaginal discharge/burning/itching/odor) or in the penis (such as redness/itching/swelling of the penis, unusual discharge from the penis). However, get medical help right away if you have any pain/redness/swelling in or around the genital/anal area, along with a fever or feeling unwell.This medication may cause you to become dehydrated. This can lead to serious kidney damage. Drink plenty of fluids to prevent dehydration. Tell your doctor or pharmacist right away if you are not able to drink fluids as usual, or losing fluid (such as due to vomiting, diarrhea, or heavy sweating). Also, tell your doctor right away if you have any signs of dehydration, such as urinating less than usual, unusual dry mouth/thirst, fast heartbeat, or dizziness/lightheadedness/fainting.If you are taking dapagliflozin for diabetes, dapagliflozin does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications, or if you do not consume enough calories from food, or if you do unusually heavy exercise. Talk with your doctor or pharmacist about whether the dose of your other diabetes medication needs to be lowered. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your doctor may need to adjust your diabetes medications.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking dapagliflozin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease/failure (dialysis), dehydration, use/abuse of alcohol, low blood pressure, history of yeast infections in the vagina or penis.If you have diabetes, you may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar and a high ketone level.If you have diabetes, it may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Also, if you are eating less or not able to eat due to these conditions or any illness, this can lead to a high ketone level while you are taking this medication. Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar or ketone testing.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this drug, especially dizziness/fainting (usually when standing), dehydration, and kidney disease.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy (such as diet and medications including insulin).It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Beta-blocker medications (such as metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs.Many drugs can affect blood sugar, making it harder to control in people with diabetes. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar if you have diabetes. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet.Your urine will test positive for glucose. Make sure laboratory personnel and all your doctors know you use this drug.

(Video) Dapagliflozin 10mg | forxiga (farxiga) benefits and side effects | How does Dapagliflozin work?

OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.Lab and/or medical tests (such as kidney function, liver function, blood sugar, hemoglobin A1c, complete blood counts, cholesterol tests, ketones) may be done before you start taking this medication and while you are taking it. Keep all medical and lab appointments. Consult your doctor for more details.If you have diabetes, attend a diabetes education program to learn more about how to manage your diabetes with medications, diet, exercise, and regular medical exams. Learn the symptoms of high and low blood sugar and how to treat low blood sugar. Check your blood sugar regularly as directed.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

(Video) Ep 18: Effects of dapagliflozin on postprandial lipid metabolism in type 2 diabetes mellitus

STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised March 2022. Copyright(c) 2022 First Databank, Inc.

(Video) How does Dapagliflozin work? Understanding SGLT2 inhibitors.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

FAQs

What are the indications for FARXIGA? ›

FARXIGA is indicated: to reduce the risk of sustained eGFR decline, end-stage kidney disease, cardiovascular (CV) death, and hospitalization for heart failure in adults with chronic kidney disease at risk of progression.

What is the dosing for FARXIGA? ›

To improve glycemic control, the recommended starting dose is 5 mg orally once daily. Dose can be increased to 10 mg orally once daily for additional glycemic control.

What drugs does FARXIGA interact with? ›

Farxiga (dapagliflozin) is an oral medication used to treat Type 2 diabetes.
...
Taking Xigduo XR with the following medications may increase a person's risk of developing lactic acidosis:
  • Carbonic anhydrase inhibitors (topiramate, zonisamide, acetazolamide or dichlorphenamide)
  • Ranolazine.
  • Vandetanib.
  • Dolutegravir.
  • Cimetidine.

What are the side effects of dapagliflozin? ›

Side effects of dapagliflozin
  • Thrush. Ask your pharmacist to recommend an antifungal treatment for thrush. ...
  • Back pain. If you get sudden unexpected back pain, do not try to treat it yourself. ...
  • Peeing more than normal. This is a sign that you're peeing out more sugar in your urine. ...
  • Feeling dizzy. ...
  • Mild skin rash.

What are the main side effects of Farxiga? ›

The most common side effects of FARXIGA include:

Vaginal yeast infections and yeast infections of the penis. Stuffy or runny nose and sore throat. Changes in urination, including urgent need to urinate more often, in larger amounts, or at night.

Who should not take Farxiga? ›

Who should not take Farxiga?
  • low blood sugar.
  • high cholesterol.
  • method of removing waste/poison from blood with dialysis.
  • pregnancy.
  • decreased blood volume.
  • chronic kidney disease stage 3B (moderate)
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)

Can dapagliflozin damage kidneys? ›

Sodium-glucose cotransporter 2 (SGLT2) inhibitors, including Farxiga (dapagliflozin), may cause acute kidney injury (AKI), according to the results of postmarketing studies. Farxiga's product label and Medication Guide provide warnings about the risk of kidney injury.

What is the best time of the day to take Farxiga? ›

FARXIGA is a once-daily pill, taken in the morning, with or without food.

Does dapagliflozin lower blood pressure? ›

In conclusion, dapagliflozin 10 mg induces a modest reduction in blood pressure compared with placebo in patients with diabetes with a low risk of orthostatic reactions, regardless of baseline blood pressure.

Does dapagliflozin increase creatinine? ›

Use of FARXIGA was associated with increases in serum creatinine and decreases in eGFR (see Table 3). In patients with normal or mildly impaired renal function at baseline, serum creatinine and eGFR returned to baseline values at Week 24.

What class of drug is dapagliflozin? ›

Dapagliflozin is in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It lowers blood sugar by causing the kidneys to get rid of more glucose in the urine.

When should I take dapagliflozin? ›

You can take dapagliflozin any time of day, just try to take it at the same time every day. Swallow the tablets whole with a drink of water. Do not chew them. You can take them with or without food.

What are the contraindications of dapagliflozin? ›

Contraindications / Precautions
  • General Information. ...
  • Diabetic ketoacidosis, surgery, type 1 diabetes mellitus. ...
  • Dehydration, hypotension. ...
  • Autosomal dominant polycystic kidney disease, dialysis, hypovolemia, renal disease, renal failure, renal impairment.

What are the benefits of dapagliflozin? ›

Dapagliflozin also lowers blood pressure due to its natriuresis effect. It improves levels of visceral fat and reduces body weight, and thus ameliorates metabolic syndrome. Dapagliflozin reduces oxidative stress and may delay atherosclerosis.

What is the drug dapagliflozin used for? ›

Dapagliflozin is mainly used to treat type 2 diabetes. It can also be used to treat heart failure. Dapagliflozin is usually prescribed if: you have type 2 diabetes and cannot take metformin.

Do the side effects of Farxiga go away? ›

Most of Farxiga's side effects are mild, and they may go away after your body adjusts to taking the medication.

Is fatigue a side effect of Farxiga? ›

Get medical help right away if you have any very serious side effects, including: unusual tiredness, nausea/vomiting, stomach/abdominal pain, trouble breathing.

Is dapagliflozin a diuretic? ›

Dapagliflozin is a relatively newly introduced anti-diabetic drug, however, it demonstrates outstanding diuretic effects that put it among the lines of treatment used for HF in DM patients.

Is Farxiga hard on kidneys? ›

Farxiga causes you to lose more sodium and water in your urine than usual. This can sometimes lead to dehydration, a condition in which your body loses too much fluid. Dehydration can cause low blood pressure. It can also damage your kidneys and lead to acute (sudden) kidney failure.

Does Farxiga improve kidney function? ›

Protect life: FARXIGA helps protect your patients with CKD at risk of progression against worsening kidney function, ESKD, CV death, and hospitalization for heart failure—so they can live life. *By slowing eGFR decline. Sustained ≥50% eGFR decline, ESKD, and CV or renal death.

Does Farxiga raise potassium levels? ›

“The co-administration of dapagliflozin (Farxiga, AstraZeneca) and potassium-sparing agents – including spironolactone – did not produce an increase in potassium levels; and the rate of significant hyperkalemia was numerically lower with dapagliflozin versus placebo in patients treated with potassium-sparing agents at ...

Does dapagliflozin increase urine output? ›

Dapagliflozin increased urinary glucose excretion by 217.2 mmol/24 h (95% confidence interval (CI): from 155.7 to 278.7, p < 0.01) and urinary osmolality by 60.4 mOsmol/kg (from 30.0 to 90.9, p < 0.01), compared to placebo.

Who is a candidate for Farxiga? ›

For adults with chronic kidney disease (CKD), FARXIGA is a prescription medicine approved to reduce the risk of further worsening of kidney disease, end-stage kidney disease, death due to cardiovascular disease, and hospitalization for heart failure.

What does dapagliflozin do for the heart? ›

If you have heart failure, dapagliflozin reduces the amount of work your heart has to do to pump blood around your body. This helps improve the symptoms of heart failure such as breathlessness, tiredness and swelling in your lower legs. It also reduces the chances of your heart getting weaker.

Can you take vitamin D with Farxiga? ›

4. Can you take vitamin D with Farxiga? Farxiga increases the risk of low blood sugar levels in the blood. Hence, Farxiga should not be taken with certain other drugs, including vitamins and supplements.

Can I take metformin and Farxiga at the same time? ›

Farxiga and metformin (Glumetza, Riomet) are commonly used together to treat type 2 diabetes. In clinical studies, taking Farxiga plus metformin reduced blood sugar levels, HbA1c, and weight more than when either drug was taken by itself.

Are there any lawsuits against Farxiga? ›

Invokana and Farxiga lawsuits account for most of the SGLT2 inhibitor diabetes drug cases filed in federal court. Plaintiffs' injuries include amputations, kidney damage, diabetic ketoacidosis and a flesh-eating disease called Fournier's gangrene.

Is Farxiga used for heart failure? ›

Today, the U.S. Food and Drug Administration approved Farxiga (dapagliflozin) oral tablets for adults with heart failure with reduced ejection fraction to reduce the risk of cardiovascular death and hospitalization for heart failure.

Does dapagliflozin cause hypoglycemia? ›

This medicine may cause hypoglycemia (low blood sugar). This is more common when this medicine is taken together with other diabetes medicines (eg, insulin, glipizide, or glyburide). The symptoms of low blood sugar must be treated before they cause you to pass out. People feel different symptoms with low blood sugar.

Does Farxiga help with BP? ›

Farxiga may cause your blood pressure to drop. This is more likely when you first start taking Farxiga, in seniors, in people already with low blood pressure, in those taking a low sodium diet, and in those taking diuretics.

Is Farxiga better than metformin? ›

Farxiga has an average rating of 4.5 out of 10 from a total of 131 ratings on Drugs.com. 28% of reviewers reported a positive effect, while 52% reported a negative effect. Metformin has an average rating of 6.9 out of 10 from a total of 617 ratings on Drugs.com.

What does Farxiga do for kidneys? ›

Farxiga is a once-daily oral tablet that belongs to a class of medications called sodium-glucose cotransporter 2 (SGLT2) inhibitors. It helps your kidneys get rid of extra blood sugar in the body.

Does Farxiga lower creatinine levels? ›

FARXIGA increases serum creatinine and decreases eGFR. Elderly patients and patients with impaired renal function may be more susceptible to these changes.

Can metformin and Farxiga be taken together? ›

Farxiga and metformin (Glumetza, Riomet) are commonly used together to treat type 2 diabetes. In clinical studies, taking Farxiga plus metformin reduced blood sugar levels, HbA1c, and weight more than when either drug was taken by itself.

Which is safer Farxiga or Jardiance? ›

The key difference between these drugs lies in the type of heart disease complications they're approved to help prevent. Jardiance is approved to reduce the risk of death from heart attacks, stroke, and heart failure. Farxiga, on the other hand, is approved to reduce the risk of hospitalization from heart failure.

Are there any lawsuits against Farxiga? ›

Invokana and Farxiga lawsuits account for most of the SGLT2 inhibitor diabetes drug cases filed in federal court. Plaintiffs' injuries include amputations, kidney damage, diabetic ketoacidosis and a flesh-eating disease called Fournier's gangrene.

Does Farxiga help lower A1C? ›

FARXIGA is a once-daily pill proven to help lower A1C, along with diet and exercise. *Average reduction with 5mg + metformin XR when starting at 9.2% A1C. Metformin XR alone lowered A1C by 1.4% when starting at 9.1% A1C. Individual results may vary.

Does Farxiga improve GFR? ›

Protect life: FARXIGA helps protect your patients with CKD at risk of progression against worsening kidney function, ESKD, CV death, and hospitalization for heart failure—so they can live life. *By slowing eGFR decline. Sustained ≥50% eGFR decline, ESKD, and CV or renal death. Over the median follow-up of 2.4 years.

Does dapagliflozin increase creatinine? ›

There was an increase in the 24-h urine glucose:creatinine ratio with dapagliflozin compared with placebo (Table 3; Figure 2). The dapagliflozin groups experienced mean weight loss, whereas there was an increase in the placebo group (Figure 2 and Table 3).

Who is a candidate for Farxiga? ›

For adults with chronic kidney disease (CKD), FARXIGA is a prescription medicine approved to reduce the risk of further worsening of kidney disease, end-stage kidney disease, death due to cardiovascular disease, and hospitalization for heart failure.

When is dapagliflozin contraindicated? ›

use dapagliflozin with caution in patients with risk factors for DKA, (including a low beta cell reserve, conditions leading to restricted food intake or severe dehydration, sudden reduction in insulin, increased insulin requirements due to acute illness, surgery or alcohol abuse), and discuss these risk factors with ...

When is the best time to take dapagliflozin? ›

You can take dapagliflozin any time of day, just try to take it at the same time every day. Swallow the tablets whole with a drink of water. Do not chew them. You can take them with or without food.

Does dapagliflozin cause kidney damage? ›

Conclusions: Dapagliflozin reduced the risk of kidney failure, death from cardiovascular causes or hospitalization for heart failure, and prolonged survival in people with chronic kidney disease, with or without type 2 diabetes, independently of the presence of concomitant cardiovascular disease.

What are the side effects of dapagliflozin metformin? ›

Dapagliflozin and metformin is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
...
Common side effects may include:
  • genital infections;
  • headache;
  • nausea, vomiting, diarrhea; or.
  • runny or stuffy nose, sore throat.
6 May 2022

Can Farxiga cause pancreatitis? ›

History of pancreatitis.

If you have type 2 diabetes and have had pancreatitis in the past, Farxiga may increase your risk of ketoacidosis. If you have type 2 diabetes and a history of pancreatitis, talk with your doctor about whether Farxiga is right for you.

Which is better metformin or dapagliflozin? ›

Dapagliflozin works in the kidneys to prevent absorption of glucose (blood sugar). This helps lower the blood sugar level. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better.

Videos

1. Farxiga for the Treatment of Type II Diabetes
(Riverside Rx Services)
2. Highlight on Dapagliflozin in Patients with Chronic Kidney Disease.prof. Amr El-Husseini,24 Sep 2020
(Academy of Kidney Diseases and Transplantation)
3. Diabetes medications - Dapagliflozin and Metformin (Xigduo)
(Dr. Andras Fazakas)
4. HFA 2020: Dapagliflozin and diuretic use in patients with HFrEF in DAPA-HF — Dr Alice M Jackson
(Radcliffe)
5. Pharmacology Series: Updates in Guidelines for Chronic Conditions: “Diabetes”
(Norton Healthcare)
6. ACC House Call: Dapagliflozin for Heart Failure
(HCPLive)
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