Type 2 Diabetes Subtypes (2023)

Type 2 diabetes is diagnosed based on high blood glucose (sugar) levels, or hyperglycemia. However, the degree to which the body is affected and the factors that led to type 2 diabetes determine how healthcare providers classify the disease.

The subtypes of type 2 diabetes differ in their characteristics and also have different risks of diabetes-related complications and outcomes. This article discusses the four main subtypes of diabetes related to type 2 diabetes, including their causes and risks for complications.

Type 2 Diabetes Subtypes (1)

Severe Insulin-Deficient Diabetes (SIDD)

Severe insulin-deficient diabetes is a subtype resembling another subtype called severe autoimmune diabetes (SAID). People with SIDD tend to be young, have a lower-than-average body mass index (BMI), and have higher hemoglobin A1c levels (an indicator of average blood glucose over the past several weeks) at diagnosis.

Due to damaged beta cells (the cells that produce insulin) in the pancreas, with SIDD, insulin production also is low. Insulin is a hormone that allows cells to take in glucose to use for energy. Treatment for people with SIDD may include insulin as well as oral medications.

Retinopathy in SIDD

The SIDD subtype seems to have a high risk of retinopathy (disease of the retina, the light-sensitive retina of the eye), and subsequently, vision loss.

Diabetic eye disease develops when high blood glucose levels cause damage to tiny blood vessels in the eye. It can eventually lead to vision loss and blindness. If you have diabetes, it’s very important to get regular eye exams to help with early detection and treatment.

Severe Autoimmune Diabetes (SAID) in Type 1 Diabetes

Severe autoimmune diabetes is a subtype of type 1 diabetes. In people with this subtype, the immune system produces antibodies that destroy the beta cells within the pancreas. This is known as an autoimmune response.

The difference between SAID and SIDD is that antibodies are not present in people with SAID, which means the immune system isn't the root cause of their diabetes. People with SAID and type 1 diabetes require insulin replacement therapy via injection or insulin pump due to their bodies not producing insulin on their own.

People with SIDD subtype diabetes have insufficient beta cell function, but the reason is unknown.

Severe Insulin-Resistant Diabetes (SIRD)

Severe insulin-resistant diabetes is a subtype characterized by high insulin resistance. This means the body is still making insulin but doesn't properly respond to it. People with SIRD tend to be overweight, which can further contribute to insulin resistance.

People with SIRD have a higher risk of developing nephropathy (kidney disease) and nonalcoholic fatty liver disease (NAFLD).

Identifying people with this subtype of diabetes may help healthcare providers further identify those at the highest risk for kidney and liver disease. With this information, a provider can develop treatment plans to help prevent or delay kidney disease and NAFLD onset and progression.

SIRD and the Risk for Kidney Disease and Fatty Liver

The SIRD subtype of diabetes is strongly associated with a high risk of nephropathy (kidney disease) and nonalcoholic fatty liver disease (NAFLD).

Kidney disease can develop in people with diabetes when blood vessels within the kidneys are damaged due to high blood glucose levels. In turn, this may also lead to high blood pressure, which can cause additional damage to the kidneys.

NAFLD is strongly associated with overweight/obesity and insulin resistance. Other risk factors for NAFLD include having metabolic syndrome (a group of conditions that can lead to type 2 diabetes, heart disease, and stroke), high triglycerides (a type of fat in the blood), and low levels of high-density lipoprotein (HDL) cholesterol, considered the "good" cholesterol.

(Video) Type 2 Diabetes Subtypes and Risks Related to Race, Ethnicity

Mild Obesity-Related Diabetes (MOD)

Mild obesity-related diabetes (MOD) is characterized by a high body mass index, but not insulin resistance. This subtype is considered a milder form of diabetes. It does not come with as many metabolic issues as the other subtypes.

Due to low levels of insulin resistance and high BMI seen in people with MOD, it is believed to be brought on by problems caused by overweight and obesity.

BMI

Body mass index is a dated, biased measure that doesn’t account for several factors, such as body composition, ethnicity, race, gender, and age.Despite being aflawed measure, BMI is widely used today in the medical community because it is an inexpensive and quick method for analyzing potential health status and outcomes.

Mild Age-Related Diabetes (MARD)

Mild age-related diabetes (MARD) is characterized by older age and late-onset of diabetes. This subtype appears to be the most common. People with MARD have mild difficulty with managing their blood glucose levels and have a low risk of complications. This is the most common subtype of diabetes.

Summary

Research has identified different clusters, or subtypes, of type 2 diabetes. These subtypes are determined based on the degree to which the body is affected and the causes or factors that led to the development of diabetes in individuals.

The subtypes include severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD).

A Word From Verywell

With diabetes being a complex condition, classifying people into different subtypes of diabetes may help develop individualized treatment plans—targeting people who will benefit the most from certain therapies and prevention measures. Knowing your subtype of diabetes can lay the foundation for more personalized diabetes care.

Frequently Asked Questions

  • What’s the difference between type 1 and type 2 diabetes?

    Both type 1 and type 2 diabetes are chronic (long-term) medical conditions. While type 1 diabetes is an autoimmune condition, type 2 diabetes is often a result of insulin resistance (the body is not able to properly use insulin).

    (Video) Diabetes mellitus (type 1, type 2) & diabetic ketoacidosis (DKA)

    People with type 2 diabetes can usually still make some insulin in their body, whereas people with type 1 diabetes cannot and require exogenous (from outside the body) insulin in order to survive.

    Learn More:Type 1 vs. Type 2 Diabetes: What Are the Differences?

  • Which type of diabetes is most serious?

    All types of diabetes are serious medical conditions. However, when looking at the subtypes of diabetes, patients who have SIRD are at the highest risk of developing nephropathy (kidney disease) and nonalcoholic fatty liver disease (NAFLD). People with SIDD are at the highest risk of developing retinopathy, a type of eye disease.

    Early detection and proper treatment are important in preventing or delaying disease progression and complications.

  • Are there different degrees of type 2 diabetes?

    Research has identified different clusters, or subtypes, of type 2 diabetes based on the causes or factors that led to an individual's diabetes, as well as the disease progression and development of complications.

    This includes severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD).

    Learn More:Types of Diabetes Mellitus

    (Video) Reversing Type 2 diabetes starts with ignoring the guidelines | Sarah Hallberg | TEDxPurdueU

8 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

  1. Ahlqvist E, Prasad RB, Groop L. Subtypes of type 2 diabetes determined from clinical parameters. Diabetes. 2020;69(10):2086-2093. doi:10.2337/dbi20-0001

  2. Sarría-Santamera A, Orazumbekova B, Maulenkul T, Gaipov A, Atageldiyeva K. The identification of diabetes mellitus subtypes applying cluster analysis techniques: a systematic review. Int J Environ Res Public Health. 2020;17(24):9523. doi:10.3390/ijerph17249523

  3. National Eye Institute. Diabetic retinopathy.

  4. Zhao YC, Zhao GJ, Chen Z, She ZG, Cai J, Li H. Nonalcoholic fatty liver disease: an emerging driver of hypertension.Hypertension. 2020;75(2):275-284. doi:10.1161/HYPERTENSIONAHA.119.13419

  5. Dharmalingam M, Yamasandhi PG. Nonalcoholic fatty liver disease and type 2 diabetes mellitus. Indian J Endocrinol Metab. 2018;22(3):421-428. doi:10.4103/ijem.IJEM_585_17

  6. American Liver Foundation. NASH causes and risk factors.

  7. National Guideline Centre (UK). Non-Alcoholic Fatty Liver Disease: Assessment and Management. London: National Institute for Health and Care Excellence (NICE); July 2016.

  8. Centers for Disease Control and Prevention. What is diabetes?

    (Video) Diabetes, Five types (clusters)

Type 2 Diabetes Subtypes (2)

By Brittany Poulson, MDA, RDN, CD, CDCES
Brittany Poulson, MDA, RDN, CDCES, is a registered dietitian and certified diabetes care and education specialist.

FAQs

Are there subtypes of type 2 diabetes? ›

Similar to subtypes of type 1 diabetes, type 2 diabetes may show four subtype clusters. They are cluster A: severe insulin-deficient diabetes, B: severe insulin-resistant diabetes, C: mild obesity-related diabetes, and D: mild age-related diabetes.

How many subtypes of diabetes are there? ›

Diabetes mellitus (DM) is a group of metabolic disorders that cause sustained high blood sugar levels. In the past, only two types of diabetes were known, type 1 and type 2. Gestational diabetes is a third type which occurs only during pregnancy. Now, DM has been reclassified into five subtypes.

What are some subtypes of diabetes? ›

Recently, Alhqvist and colleagues using K-means cluster analysis (CA) has proposed a novel classification of adult onset DM into five subgroups: Severe Autoimmune Diabetes (SAID); Severe Insulin-Deficient Diabetes (SIDD); Severe Insulin-Resistant Diabetes (SIRD); Mild Obesity-Related Diabetes (MOD); and Mild Age- ...

How do type 1 and type 2 diabetes differ Be sure to answer this in detail? ›

The main difference between the type 1 and type 2 diabetes is that type 1 diabetes is a genetic condition that often shows up early in life, and type 2 is mainly lifestyle-related and develops over time. With type 1 diabetes, your immune system is attacking and destroying the insulin-producing cells in your pancreas.

What is Mody diabetes? ›

MODY stands for “Maturity-onset diabetes of the young” and was given that name in the past because it acted more like adult type of diabetes (Type 2 Diabetes) but was found in young people. MODY limits the body's ability to produce insulin, but is different than the juvenile type of diabetes (Type 1 Diabetes).

What is Lada in diabetes? ›

Latent autoimmune diabetes in adults (LADA) is a slow-progressing form of autoimmune diabetes. Like the autoimmune disease type 1 diabetes, LADA occurs because your pancreas stops producing adequate insulin, most likely from some "insult" that slowly damages the insulin-producing cells in the pancreas.

Videos

1. ARC Seminars: 5 Diabetes Subtypes - Information that will change your practice!
(ARC Seminars LLC)
2. Classifying diabetes type in ethnic groups
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3. Type 2 diabetes subgroups: ethnicity and outcomes
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4. Researching the causes and prevention of type 2 diabetes
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5. Obesity and Type 2 Diabetes - Health Matters
(University of California Television (UCTV))
6. Stanford Doctor on Type 2 Diabetes in Asian Americans
(Stanford Health Care)
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